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KMID : 0359720170350010022
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Journal of the Korean Neurological Association
2017 Volume.35 No. 1 p.22 ~ p.25
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Subacute Combined Degeneration Caused by Chronic Atrophic Gastritis with Spurious Elevation of Vitamin B12 Level
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Park Jae-Gun
Lee Ho-Sun
Park Min-Su
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Abstract
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We report a patient who was diagnosed as subacute combined degeneration (SCD) with elevated homocysteine and methylmalonic acid levels in the situation of a spurious elevation of the vitamin B12 concentration. A false-positive elevation of the vitamin B12 level could lead to a delayed diagnosis and cause irreversible changes in the nervous systems. We therefore suggest that the homocysteine and methylmalonic acid levels should be checked in patients with a normal or elevated vitamin B12 level for whom there is a high clinical suspicion for vitamin B12 deficiency, as a further evaluation for SCD.
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KEYWORD
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Subacute combined denegenration, Methylmalonic acid, Homocysteine
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